Vancomycin Minimum Inhibitory Concentrations and Outcome in Patients With Severe Staphylococcus aureus Infection

Vancomycin minimum inhibitory concentrations and outcome in patients with severe Staphylococcus aureus infection.

To the Editor—As Holland and Fowler point out in their excellent commentary [1], there are many unresolved issues in the measurement and clinical interpretation of vancomycin minimum inhibitory concentrations (MICs). There is, however, one major omission from their otherwise comprehensive review of published, peer-reviewed outcome studies versus MIC in serious methicillin-resistant Staphylococc...

Antibiotic choice may not explain poorer outcomes in patients with Staphylococcus aureus bacteremia and high vancomycin minimum inhibitory concentrations.

BACKGROUND There are concerns about reduced efficacy of vancomycin in patients with Staphylococcus aureus bacteremia (SAB), especially when the minimum inhibitory concentration (MIC) nears the upper limit of the susceptible range. METHODS We examined the relationship between antibiotic treatment, 30-day mortality, and microbiologic parameters in a large Australasian cohort of patients with SA...

Vancomycin minimum inhibitory concentrations using different susceptibility methods in Staphylococcus aureus isolates.

Minimum Inhibitory Concentration of Staphylococcus Aureus against Vancomycin

The main objective of this investigation is to find out the minimum inhibitory concentration (MIC) of Staphylococcus aureus with reduced inclination to vancomycin among 30 clinical isolates of methicillin-resistance Staphylococcus aureus (MRSA) and was screened by Etest and broth dilution methods. The comparative analysis of MIC for vancomycin by broth dilution and Etest methods discloses that ...

Role of high vancomycin minimum inhibitory concentration in the outcome of methicillin-susceptible Staphylococcus aureus bacteremia.

Correspondence Role of High Vancomycin Minimum Inhibitory Concentration in the Outcome of Methicillin-Susceptible Staphylococcus aureus Bacteremia To the Editor—We read with great interest the article by Holmes et al [1] and the editorial commentary published in the same issue [2] regarding the novel topic of the potential role of high minimum inhibitory concentration (MIC) levels of vancomycin...